Endocrine Abstracts

Background: Diagnostic thyroid scans using technetium-99m pertechnetate are widely used to differentiate the causes of hyperthyroidism. Only 1-5% of the administered isotope is taken up by the thyroid after 20 minutes resulting in high background radioactivity.Objectives: To determine the effective radiation dose and calculated organ doses after a standard administration of Technetium-99m pertechnetate</ce:under...

Background: Mutations in the RET proto-oncogene occur in about 70% of medullary thyroid cancers (MTC) and is central in its pathogenesis. Two highly selective RET inhibitors, selpercatinib and pralsetinib, are FDA/EMA-approved in RET-altered thyroid cancers. We share our experience of these drugs in metastatic MTC.Methods: Data were collected retrospectively from 19 patients commenced on selective RET inhibitors for MTC ...